The U.S. Coast Guard says it suspended the search at 4:42 p.m. for a crewman lost off the fishing vessel Glacier Spirit near Sand Point.
Coast Guard aircraft spent about six hours searching more than 40 square miles without any sightings of the missing crewman.
The Coast Guard said it received a call at 10:26 a.m. from the Alaska Department of Fish and Game requesting assistance in searching for the crewman.
"My thought and prayers are with the victim's family and friends," said Capt. Daniel Travers, 17th Coast Guard District chief of incident management. "Suspending a search without finding the person you're looking for is one of the hardest decisions for the Coast Guard to make."
The Coast Guard hasn't yet released the victim's name.
State records list the owner of the 47-foot Glacier Spirit as Richard Eastlick of Sand Point.